Recent CIG Publications


Full Study Title: AntiPhospholipid Syndrome Low-molecular-weight Heparin Pregnancy Loss Evaluation: The Pilot Study

Principal Investigators: Leslie Skeith, Marc Rodger

Funding: CanVECTOR Pilot, LEO (Leo Pharma)

Design: Open-label pilot RCT of antepartum prophylaxis with LMWH and ASA versus ASA alone in women with confirmed antiphospholipid syndrome (APS) and a history of past pregnancy loss

Study Publication:

For more informationNCT03100123


Full Study Title: Apixaban for the Prevention of Venous Thromboembolism in Cancer Patients

Principal Investigators: Marc Carrier, Phil Wells

Funding: CIHR (Canadian Institutes of Health Research), BMS (BMS Pfizer (Bristol-Myers Squibb Pfizer)

For more information: NCT02048865


02. Catheter 2

Full Study Title: Study in Cancer Patients With Central Line Associated Clots in the Upper Extremity Treated With Rivaroxaban

Principal Investigator: Michael J. Kovacs

Study Publication


Full Study Title: Extended Venous Thromboembolism Prophylaxis Comparing Rivaroxaban to Aspirin Following Total Hip and Knee Arthroplasty

Principal Investigator: David Anderson

Funding: CIHR (Canadian Institutes of Health Research)

Design: Double-blind RCT (randomized clinical trial) of rivaroxaban vs. aspirin for total knee and total hip arthroplasty

For more information: NCT01720108

Study Publication:


Full Study Title: Perioperative Anticoagulant Use for Surgery Evaluation Study

Principal Investigator: Jim Douketis

Funding: CIHR (Canadian Institutes of Health Research), HSF (Heart and Stroke Foundation of Canada)

Design: Prospective cohort study of patients with atrial fibrillation on new oral anticoagulants requiring interruption for elective surgery/procedure; looking to develop a safer perioperative protocol

For more information: NCT02228798

Study Publication:


06. PEGeD

Full Study Title: D-dimer Testing Tailored to Clinical Pretest Probability in Suspected Pulmonary Embolism

Principal Investigators: Clive Kearon

Funding: Canadian Institutes of Health Research (CIHR)

Design: Prospective, multi-centre, cohort study that will assess a new diagnostic management strategy for suspected Pulmonary Embolism (inpatients and outpatients.

For more information: NCT02483442

Study Publication:

07. RAPS

Full Study Title: Rivaroxaban for Antiphospholipid Antibody Syndrome

Principal Investigators: Mark Crowther, Kimberly Legault

Funding: HSF (Heart and Stroke Foundation of Canada), Bayer

Design: Pilot prospective management study of rivaroxaban for patients with antiphospholipid antibody syndrome

Study Publication:


Full Study Title: Clinical Decision Rule Validation Study to Predict Low Recurrent Risk in Patients With Unprovoked Venous Thromboembolism

Principal Investigator: Marc Rodger

Funding: Funded by a grant from the French Ministry of Health (PHRC 2009-08-05) and BioMerieux

Study Publication

09. TRIM-Line Pilot

Principal Investigators: Rick Ikesaka, Marc Carrier

Funding: CanVECTOR Pilot

Design: Pilot double-blind placebo-controlled RCT (randomized clinical trial) investigating primary thromboprophylaxis with rivaroxaban in patients with malignancy and central venous catheters.

Study Publication


Full Study Title: Prothrombin Complex Concentrate for Major Bleeding on Factor Xa Inhibitors: A Prospective Cohort Study

Principal Investigator: Sam Schulman

Funding: Octapharma

Study Publication (Abstract):