Full Study Title: AntiPhospholipid Syndrome Low-molecular-weight Heparin Pregnancy Loss Evaluation: The Pilot Study
Principal Investigators: Leslie Skeith, Marc Rodger
Funding: CanVECTOR Pilot, LEO (Leo Pharma)
Design: Open-label pilot RCT of antepartum prophylaxis with LMWH and ASA versus ASA alone in women with confirmed antiphospholipid syndrome (APS) and a history of past pregnancy loss
Study Publication: https://www.thrombosisresearch.com/article/S0049-3848(20)30207-3/pdf
For more information: NCT03100123 https://clinicaltrials.gov/
Full Study Title: Apixaban for the Prevention of Venous Thromboembolism in Cancer Patients
Principal Investigators: Marc Carrier, Phil Wells
Funding: CIHR (Canadian Institutes of Health Research), BMS (BMS Pfizer (Bristol-Myers Squibb Pfizer)
For more information: NCT02048865 https://clinicaltrials.gov/
Publication: https://www.nejm.org/doi/full/10.1056/NEJMoa1814468
Full Study Title: Study in Cancer Patients With Central Line Associated Clots in the Upper Extremity Treated With Rivaroxaban
Principal Investigator: Michael J. Kovacs
Study Publication: http://www.sciencedirect.com/science/article/pii/S0049384817302578?via%3Dihub
Full Study Title: Extended Venous Thromboembolism Prophylaxis Comparing Rivaroxaban to Aspirin Following Total Hip and Knee Arthroplasty
Principal Investigator: David Anderson
Funding: CIHR (Canadian Institutes of Health Research)
Design: Double-blind RCT (randomized clinical trial) of rivaroxaban vs. aspirin for total knee and total hip arthroplasty
For more information: NCT01720108 https://clinicaltrials.gov/
Study Publication: http://www.nejm.org/doi/full/10.1056/NEJMoa1712746
Full Study Title: Perioperative Anticoagulant Use for Surgery Evaluation Study
Principal Investigator: Jim Douketis
Funding: CIHR (Canadian Institutes of Health Research), HSF (Heart and Stroke Foundation of Canada)
Design: Prospective cohort study of patients with atrial fibrillation on new oral anticoagulants requiring interruption for elective surgery/procedure; looking to develop a safer perioperative protocol
For more information: NCT02228798 https://clinicaltrials.gov/
Study Publication: https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2740207
Full Study Title: D-dimer Testing Tailored to Clinical Pretest Probability in Suspected Pulmonary Embolism
Principal Investigators: Clive Kearon
Funding: Canadian Institutes of Health Research (CIHR)
Design: Prospective, multi-centre, cohort study that will assess a new diagnostic management strategy for suspected Pulmonary Embolism (inpatients and outpatients.
For more information: NCT02483442 https://clinicaltrials.gov/
Study Publication: https://www.nejm.org/doi/pdf/10.1056/NEJMoa1909159?articleTools=true
Full Study Title: Rivaroxaban for Antiphospholipid Antibody Syndrome
Principal Investigators: Mark Crowther, Kimberly Legault
Funding: HSF (Heart and Stroke Foundation of Canada), Bayer
Design: Pilot prospective management study of rivaroxaban for patients with antiphospholipid antibody syndrome
Study Publication: https://pilotfeasibilitystudies.biomedcentral.com/articles/10.1186/s40814-020-00594-1
Full Study Title: Clinical Decision Rule Validation Study to Predict Low Recurrent Risk in Patients With Unprovoked Venous Thromboembolism
Principal Investigator: Marc Rodger
Funding: Funded by a grant from the French Ministry of Health (PHRC 2009-08-05) and BioMerieux
Study Publication: http://www.bmj.com/content/356/bmj.j1065
Principal Investigators: Rick Ikesaka, Marc Carrier
Funding: CanVECTOR Pilot
Design: Pilot double-blind placebo-controlled RCT (randomized clinical trial) investigating primary thromboprophylaxis with rivaroxaban in patients with malignancy and central venous catheters.
Study Publication: https://academy.isth.org/isth/2020/milan/297236/rick.ikesaka.thromboprophylaxis.with.rivaroxaban.in.patients.with.malignancy.html
Full Study Title: Prothrombin Complex Concentrate for Major Bleeding on Factor Xa Inhibitors: A Prospective Cohort Study
Principal Investigator: Sam Schulman
Funding: Octapharma
Study Publication (Abstract): https://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1636541