Active Studies: Completed Recruitment

01. AVERT

Full Study Title: Apixaban for the Prevention of Venous Thromboembolism in Cancer Patients

Principal Investigators: Marc Carrier, Phil Wells

Funding: CIHR (Canadian Institutes of Health Research), BMS (BMS Pfizer (Bristol-Myers Squibb Pfizer)

Design: Double-blind RCT (randomized clinical trial) of apixaban for VTE (Venous Thromboembolism) prophylaxis in patients with cancer and chemotherapy treatment

For more information: NCT02048865 https://clinicaltrials.gov/

 

02. BLEEDING RISK

Full Study Title: Predicting Bleeding Risk on Anticoagulant Therapy for Venous Thromboembolism

Principal Investigator: Phil Wells

Funding: HSF (Heart and Stroke Foundation of Canada)

Design: Cohort study of VTE (Venous Thromboembolism) patients on anticoagulants to derive a decision rule for bleeding

For more information: NCT00788736 https://clinicaltrials.gov/

Published Abstract: ISTH 2017 - Research and Practice in Thrombosis and Haemostasis: Bleed Risk 

 

03. COBRRA Pilot

Full Study Title: Comparison of Bleeding Risk Between Rivaroxaban and Apixaban

Principal Investigator: Lana Castellucci

Funding: CanVECTOR Pilot

Design: Open-label pilot RCT (randomized clinical trial) comparing bleeding risk with rivaroxaban versus apixaban

For more information: NCT02559856 https://clinicaltrials.gov/

04. PERIOP 2

Full Study Title: A Safety and Effectiveness of LMWH vs Placebo Bridging Therapy for Patients on Long Term Warfarin Requiring Temporary Interruption of Warfarin

Principal Investigator: Michael Kovacs

Funding: CIHR (Canadian Institutes of Health Research), Pfizer

Design: Double-blind RCT (randomized clinical trial) of post-procedure bridging with LMWH (low-molecular-weight heparin) versus placebo for patients on long-term warfarin who require temporary interruption of warfarin

For more information: NCT00432796 https://clinicaltrials.gov/

 

05. PEGED

Full Study Title: D-dimer Testing Tailored to Clinical Pretest Probability in Suspected Pulmonary Embolism

Principal Investigator: Clive Kearon

Funding: CIHR (Canadian Institutes of Health Research)

Design: Prospective cohort study to assess a new diagnostic management strategy for suspected pulmonary embolism in outpatients

For more information: NCT02483442 https://clinicaltrials.gov/

06. RASET

Full Study Title: Rivaroxaban Anticoagulation for Superficial Vein Thrombosis

Principal Investigator: Clive Kearon

Funding: Bayer

Design: Double-blind RCT (randomized clinical trial) of rivaroxaban versus placebo for treatment of superficial vein thrombosis

For more information: NCT02123524 https://clinicaltrials.gov/

07. RAPS

Full Study Title: Rivaroxaban for Antiphospholipid Antibody Syndrome

Principal Investigators: Mark Crowther, Kimberly Legault

Funding: HSF (Heart and Stroke Foundation of Canada), Bayer

Design: Pilot prospective management study of rivaroxaban for patients with antiphospholipid antibody syndrome

For more information: NCT02116036 https://clinicaltrials.gov/